Download scientific diagram | – Cnidoscolus quercifolius plant. from publication: Análise Química e Bromatológica da Forragem da Faveleira (Cnidoscolus. PDF | Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential. The Cnidoscolus quercifolius (Pohl) popularly known as “favela” or “faveleira” is a forager that is part of the native species from the caatinga.

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Despite the negative presence of alkaloids in the faveleira extracts tested, the plant presented satisfactory activity of enzyme inhibition, when compared with the reference substance, raising the possibility that new untested substances may act on the inhibition of AChE.

De Almeida Alves, A. All the methanolic extracts of the faveleira presented anticholinesterase activity. The results suggest that the substances present in faveleira Cnidoscolus quercifolius root bark extract have a cytotoxic potential against several tumor lines, showing a broader antitumour potential, and in addition no adverse to healthy cells.


Disks containing Streptomycin 1. The authors expect to develop a new herbal product, resulting in lower production costs and that, consequently, could be commercialized in more accessible form to the population, highlighting the risk reduction of contraindication of this category of medications. The extract from the bark of C. Studies have shown that plants used cnkdoscolus traditional medicine have the effect cnidoscoolus prevention and protection under conditions of oxidative stress [ 38 — 40 ].

Evidence-Based Complementary and Alternative Medicine

According to Ribeiro and Brito [ 15 ], the faveleira can be used for forestation, recovery of degraded areas, animal and human consumption, medicine, timber, and energy. The methodology began with the collection and herborization of the plant material, to obtain the chemical compounds, preliminary phytochemical analysis, and extraction of the constituents of the active extracts. Several studies have shown the use of Artemia salina to evaluate the toxicity of extracts, of isolated and purified substances of medicinal plants [ 3151 — 54 quercifo,ius, thus decreasing the use of animals for experimentation.


These are samples of crude extracts and may therefore be considered a meaningful result, suggesting the need to isolate the compounds responsible for sequestering the free radicals, thus achieving an index even closer to the default.

In quercifoliua evaluation of toxicity of methanolic extracts of C. To receive news and publication updates for Evidence-Based Complementary and Alternative Medicine, enter your email address in the box below. Tests were performed for the detection of phenols and tannins, anthocyanins and anthocyanidins, flavones, flavonols, xanthones, flavanones, chalcones and aurones, leucoanthocyanidins, catechins, steroids and triterpenoids, and saponins.

As far as we know, there are no data in the literature showing the antioxidant activity of samples of C. It was the start of a series of cultural intermixes that blended the knowledge brought in by the colonizers, the slaves, and the natives. The high-performance liquid chromatography with diode-array detection and 1 H and 13 C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract.

The lethality assay against Artemia sp.

Preliminary phytochemical analysis of C. The identification of these plants, through phytochemical and ethnopharmacological studies, provides the possibility of discovery and development of new drugs that could be relevant for the treatment of degenerative diseases of the nervous system, through the effect of AChE inhibition [ 4950 ].

Antimicrobial activity of the methanolic extracts of C.

Cnidoscolus quercifolius – Wikiwand

Materials and Methods 2. The caatingaan exclusively Brazilian biome, is one of the most endangered vegetation systems in the planet.


Ahmad and Beg [ 44 ] believe that the antimicrobial effect of vegetal extracts is largely due to the presence of flavonoids in their composition, thus corroborating the results found for the C. Table 2 shows the results of antimicrobial activity of methanolic extracts of C.

Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl

This difference in the presence and absence of certain chemical compounds of plant species may be related to factors such as age of the plant and the time of collection [ 31 ]. To analyze the significance of the differences between the cnidoscoluw the authors used Variance Analysis ANOVA followed by the Newman-Keuls comparison test, being considered significant.

Da Planta ao MedicamentoC. For this reason, the present study focuses on the assessment of the therapeutic potential of this plant, by investigating its possible antioxidant, antimicrobial, and inhibitory activity of the acetylcholinesterase enzyme AChEas well as the toxicity of the methanolic extracts querckfolius three parts of Cnidoscolus quercifolius Pohl.

There was no inhibitory response from the extracts tested against Escherichia coli and Klebsiella pneumoniae strains, thus demonstrating that the methanolic extracts of faveleira showed better inhibition against strains of Gram-positive bacteria.

Preliminary Phytochemical Analysis The extracts were subjected to phytochemical screening, following the protocols described by Mattos [ 16 ]. Man has long been using plants to promote health, in the belief that they carry beneficial substances for a healthy existence.

Table of Contents Alerts. Therefore, the root bark extract of Cnidoscolus quercifolius has a possibility of use for anticarcinogenic therapies.